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Toxic shock syndroom

Advices

≥ 18 years

Indications: bij onbekende verwekker
Priority	Medication	Remarks
Priority: 1st choice	Medication: flucloxacilline iv loading dose 1g, 6g continuous per 24 hours minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days
Priority: 1st choice alternative	Medication: flucloxacilline iv 1g 6dd minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days

≥ 18 years

Indications: Bij onbekende verwekker i.c.m. penicilline-allergie
Priority	Medication	Remarks
Priority: 1st choice	Medication: cefazoline iv loading dose 2g, 6g continuous per 24 hours minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days
Priority: 1st choice alternative	Medication: cefazoline iv 2g 3dd minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days

≥ 18 years

Indications: T.g.v. Groep A streptokokken
Priority	Medication	Remarks
Priority: 1st choice	Medication: benzylpenicilline iv loading dose 2million. IU, 12million. IU continuous per 24 hours minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days
Priority: 1st choice alternative	Medication: benzylpenicilline iv 2million. IU 6dd minimum 7 days + clindamycine iv 600mg 3dd minimum 7 days

≥ 18 years

Indications: T.g.v. S. aureus toxine
Priority	Medication	Remarks
Priority: 1st choice	Medication: flucloxacilline iv loading dose 1g, 6g continuous per 24 hours minimum 7 days
Priority: 1st choice alternative	Medication: flucloxacilline iv 1g 6dd minimum 7 days

Bij groep A streptokokken: Groep A streptokokken zijn een meldingsplichtige ziekte groep B2.

The following antimicrobial agents have been used in these recommendations:

Swab vid: G-500595.1
Updated: 04/29/2025 - 11:24
Status: Published