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Endocarditis, kunstklep - empirische therapie

Advices

≥ 18 years
Priority Medication Remarks
Priority:
1st choice
Medication:

flucloxacilline iv loading dose 2g, 12g continuous per 24 hours

+

vancomycine iv continuous per 24 hours

Remarks:

Bij vancomycine volg protocol: TDM vancomycine doseringen

Plateauconcentratie: 20-25 mg/L

Priority:
1st choice alternative
Medication:

flucloxacilline iv 2g 6dd

+

vancomycine iv continuous per 24 hours

Remarks:

Bij vancomycine volg protocol: TDM vancomycine doseringen

Plateauconcentratie: 20-25 mg/L

Priority:
2nd choice
Medication:

cefazoline iv loading dose 2g, 6g continuous per 24 hours

+

vancomycine iv continuous per 24 hours

Remarks:

Bij niet-ernstige penicilline allergie

Bij vancomycine volg protocol: TDM vancomycine doseringen

Plateauconcentratie: 20-25 mg/L

General comments

Voor dosering vancomycine en spiegelbepalingen: Vancomycine dosering en TDM.

Empirische therapie aanpassen op geleide kweek, zie SWAB richtlijn

 

 

Sources

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-500942.2
Updated: 06/05/2025 - 10:52
Status: Published